human EXOC1 shRNA silencing AAV

Name
AAV-h-EXOC1-shRNA

Cat No
shAAV-208173

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human EXOC1.

shAAV-208173

AAV-h-EXOC1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human EXOC1 (exocyst complex component 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BM-102; exocyst complex component 1; exocyst complex component Sec3; SEC3; SEC3L1; SEC3-like 1; SEC3P

Description (eCommerce)

Sec3 is a component of the exocyst complex, a multisubunit complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Description (Vector)

EXOC1 is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Gene ID

55763

Gene Name (eCommerce)

exocyst complex component 1

Gene Name (Vector)

exocyst complex component 1

Gene Symbol

EXOC1

HGNC ID

HGNC:30380

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2685

ORF Size (bp)

2685 bp

Protein Name (eCommerce)

Exocyst complex component 1

RefSeq ID

NM_018261

RefSeq Synonyms

NM_178237, NM_018261, NM_001024924, BC094751,

Research Areas

Insulin Signaling,Signal Transduction,Transport

Research Areas (Faceted)

cell_biology,signal_transduction

Species

human

Target Sentence

Sec3 is a component of the exocyst complex, a multisubunit complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

UniGene ID

Hs.269665

UniProt ID (eCommerce)

Q9NV70

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.