human ETS1 shRNA silencing AAV

Name 
AAV-h-ETS1-shRNA
Cat No 
shAAV-208139
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ETS1.

shAAV-208139
AAV-h-ETS1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ETS1 (ETS proto-oncogene 1, transcription factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1; c-ets-1; ETS-1; EWSR2; p54; protein C-ets-1; v-ets avian erythroblastosis virus E2 oncogene homolog 1; v-ets avian erythroblastosis virus E26 oncogene homolog 1
Description (eCommerce)
Ets-1 is a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis [taken from NCBI Entrez Gene (Gene ID: 2113)].
Description (Vector)
ETS1 encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene ID
2113
Gene Name (eCommerce)
ETS proto-oncogene 1, transcription factor
Gene Name (Vector)
ETS proto-oncogene 1, transcription factor
Gene Symbol
ETS1
HGNC ID
HGNC:3488
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
819
ORF Size (bp)
819 bp
Protein Name (eCommerce)
Protein C-ets-1
RefSeq ID
NM_005238
RefSeq Synonyms
NM_005238, NM_001330451, NM_001162422, NM_001143820, BC017314,
Research Areas
Angiogenesis,Apoptosis,B-cell Receptor Signaling,Cancer,Cardiovascular,Cell Cycle,FGF Signaling,HGF Signaling,Host-Virus Interactions,Hypoxia,Immunology,Interleukin Signaling,Kidney Cancer,Neurobiology,Neurodevelopment,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Ets-1 is a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis [taken from NCBI Entrez Gene (Gene ID: 2113)].
UniGene ID
Hs.369438
UniProt ID (eCommerce)
P14921

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.