human ESR2 shRNA silencing AAV

Name
AAV-h-ESR2-shRNA

Cat No
shAAV-208116

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ESR2.

shAAV-208116

AAV-h-ESR2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ESR2 (estrogen receptor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2

Description (Vector)

ESR2 encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.

Gene ID

2100

Gene Name (Vector)

estrogen receptor 2

Gene Symbol

ESR2

HGNC ID

HGNC:3468

ORF Size (aa)

972

ORF Size (bp)

972 bp

RefSeq ID

NM_001437

RefSeq Synonyms

NM_001437, NM_001291723, NM_001291712, NM_001271877, NM_001271876, NM_001214903, NM_001214902, NM_001040276, NM_001040275, BC024181,

Species

human

UniGene ID

Hs.660607

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.