human EDA shRNA silencing AAV

Name
AAV-h-EDA-shRNA

Cat No
shAAV-207549

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human EDA.

shAAV-207549

AAV-h-EDA-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human EDA (ectodysplasin A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ECTD1; ED1; ED1-A1; ED1-A2; EDA-A1; EDA-A2; EDA1; EDA2; HED; HED1; ODT1; STHAGX1; TNLG7C; XHED; XLHED

Description (Vector)

EDA is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.

Gene ID

1896

Gene Name (Vector)

ectodysplasin A

Gene Symbol

EDA

HGNC ID

HGNC:3157

ORF Size (aa)

1161

ORF Size (bp)

1161 bp

RefSeq ID

NM_001005609

RefSeq Synonyms

NM_001399, NM_001005613, NM_001005612, NM_001005610, NM_001005609, BC144051, BC144049, BC126143,

Species

human

UniGene ID

Hs.105407

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.