human DPH1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DPH1.
shAAV-207273
AAV-h-DPH1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DPH1 (diphthamide biosynthesis 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DEDSSH; DPH2L; DPH2L1; OVCA1
Description (Vector)
Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 (PubMed 15485916)).(supplied by OMIM, Mar 2008)
Gene ID
1801
Gene Name (Vector)
diphthamide biosynthesis 1
Gene Symbol
DPH1
HGNC ID
HGNC:3003
ORF Size (aa)
912
ORF Size (bp)
912 bp
RefSeq ID
NM_001383
RefSeq Synonyms
NM_001383, NM_001346576, NM_001346575, NM_001346574, BC096088,
Species
human
UniGene ID
Hs.513856
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.