human DOC2B shRNA silencing AAV

Name
AAV-h-DOC2B-shRNA

Cat No
shAAV-207222

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human DOC2B.

shAAV-207222

AAV-h-DOC2B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DOC2B (double C2 domain beta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DOC2BL

Description (Vector)

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells.

Gene ID

8447

Gene Name (Vector)

double C2 domain beta

Gene Symbol

DOC2B

HGNC ID

HGNC:2986

ORF Size (aa)

1236

ORF Size (bp)

1236 bp

RefSeq ID

NM_003585

RefSeq Synonyms

NM_003585, BC153024, BC152720,

Species

human

UniGene ID

Hs.648240

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.