human DNMT3B shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DNMT3B.
shAAV-207211
AAV-h-DNMT3B-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DNMT3B (DNA methyltransferase 3 beta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ICF; ICF1; M.HsaIIIB
Description (Vector)
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
Gene ID
1789
Gene Name (Vector)
DNA methyltransferase 3 beta
Gene Symbol
DNMT3B
HGNC ID
HGNC:2979
ORF Size (aa)
2559
ORF Size (bp)
2559 bp
RefSeq ID
NM_006892
RefSeq Synonyms
NM_175850, NM_175849, NM_175848, NM_006892, NM_001207056, NM_001207055, BC118502, BC111933,
Species
human
UniGene ID
Hs.713611
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.