human DNAJC2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DNAJC2.
shAAV-207160
AAV-h-DNAJC2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DNAJC2 (DnaJ heat shock protein family (Hsp40) member C2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DnaJ (Hsp40) homolog, subfamily C, member 2; dnaJ homolog subfamily C member 2; M-phase phosphoprotein 11; MPHOSPH11; MPP11; ZRF1; ZUO1; zuotin-related factor 1
Description (eCommerce)
M-phase phosphoprotein 11 is a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. MPP11 is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. MPP11 was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Additionally, chromosomal aberrations involving the DNAJC2 gene are associated with primary head and neck squamous cell tumors [taken from NCBI Entrez Gene (Gene ID: 27000)].
Description (Vector)
DNAJC2 is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. DNAJC2 has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described.
Gene ID
27000
Gene Name (eCommerce)
DnaJ heat shock protein family (Hsp40) member C2
Gene Name (Vector)
DnaJ heat shock protein family (Hsp40) member C2
Gene Symbol
DNAJC2
HGNC ID
HGNC:13192
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1866
ORF Size (bp)
1866 bp
Protein Name (eCommerce)
DnaJ homolog subfamily C member 2
RefSeq ID
NM_001129887
RefSeq Synonyms
NM_014377, NM_001129887, BC160045, BC056682,
Research Areas
Cell Cycle,Chromatin Remodeling,DNA Replication,Transcription Factor/Regulator,Translational Control
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
M-phase phosphoprotein 11 is a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. MPP11 is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. MPP11 was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Additionally, chromosomal aberrations involving the DNAJC2 gene are associated with primary head and neck squamous cell tumors [taken from NCBI Entrez Gene (Gene ID: 27000)].
UniGene ID
Hs.558476
UniProt ID (eCommerce)
Q99543
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.