human DLK1 shRNA silencing AAV

Name
AAV-h-DLK1-shRNA

Cat No
shAAV-207054

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human DLK1.

shAAV-207054

AAV-h-DLK1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DLK1 (delta like non-canonical Notch ligand 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Delta1; DLK; DLK-1; FA1; pG2; Pref-1; PREF1; ZOG

Description (Vector)

DLK1 encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). DLK1 is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.

Gene ID

8788

Gene Name (Vector)

delta like non-canonical Notch ligand 1

Gene Symbol

DLK1

HGNC ID

HGNC:2907

ORF Size (aa)

1152

ORF Size (bp)

1152 bp

RefSeq ID

NM_003836

RefSeq Synonyms

NM_003836, NM_001317172, BC014015, BC013197, BC007741,

Species

human

UniGene ID

Hs.533717

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.