human DLC1 shRNA silencing AAV

Name
AAV-h-DLC1-shRNA

Cat No
shAAV-207033

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human DLC1.

shAAV-207033

AAV-h-DLC1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DLC1 (DLC1 Rho GTPase activating protein). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ARHGAP7; HP; p122-RhoGAP; STARD12

Description (Vector)

DLC1 encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. DLC1 functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.

Gene ID

10395

Gene Name (Vector)

DLC1 Rho GTPase activating protein

Gene Symbol

DLC1

HGNC ID

HGNC:2897

ORF Size (aa)

4587

ORF Size (bp)

4587 bp

RefSeq ID

NM_006094

RefSeq Synonyms

NM_182643, NM_024767, NM_006094, NM_001316668, NM_001164271, BC054511, BC049842,

Species

human

UniGene ID

Hs.134296

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.