human DKK2 shRNA silencing AAV

Name
AAV-h-DKK2-shRNA

Cat No
shAAV-207024

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human DKK2.

shAAV-207024

AAV-h-DKK2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DKK2 (dickkopf WNT signaling pathway inhibitor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DKK-2

Description (Vector)

DKK2 encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).

Gene ID

27123

Gene Name (Vector)

dickkopf WNT signaling pathway inhibitor 2

Gene Symbol

DKK2

HGNC ID

HGNC:2892

ORF Size (aa)

780

ORF Size (bp)

780 bp

RefSeq ID

NM_014421

RefSeq Synonyms

NM_014421, BC126330, BC126328, BC075078, BC075077,

Species

human

UniGene ID

Hs.211869

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.