human DHPS shRNA silencing AAV

Name 
AAV-h-DHPS-shRNA
Cat No 
shAAV-206940
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human DHPS.

shAAV-206940
AAV-h-DHPS-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DHPS (deoxyhypusine synthase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
deoxyhypusine synthase; DHS; DS; MIG13; migration-inducing gene 13
Description (eCommerce)
Deoxyhypusine synthase (DHPS) catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P49366].
Description (Vector)
DHPS encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
1725
Gene Name (eCommerce)
deoxyhypusine synthase
Gene Name (Vector)
deoxyhypusine synthase
Gene Symbol
DHPS
HGNC ID
HGNC:2869
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1110
ORF Size (bp)
1110 bp
Protein Name (eCommerce)
Deoxyhypusine synthase
RefSeq ID
NM_001930
RefSeq Synonyms
NM_013406, NM_001930, NM_001206974, BC014016, BC000333,
Research Areas
Metabolism/Metabolic Process,Translational Control
Research Areas (Faceted)
cell_biology,metabolism,transcription_translation
Species
human
Target Sentence
Deoxyhypusine synthase (DHPS) catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P49366].
UniGene ID
Hs.79064
UniProt ID (eCommerce)
P49366

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.