human DES shRNA silencing AAV

Name
AAV-h-DES-shRNA

Cat No
shAAV-206889

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human DES.

shAAV-206889

AAV-h-DES-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DES (desmin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CSM1; CSM2; LGMD2R

Description (Vector)

DES encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.

Gene ID

1674

Gene Name (Vector)

desmin

Gene Symbol

DES

HGNC ID

HGNC:2770

ORF Size (aa)

1413

ORF Size (bp)

1413 bp

RefSeq ID

NM_001927

RefSeq Synonyms

NM_001927, BC032116,

Species

human

UniGene ID

Hs.594952

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.