human DDIT3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DDIT3.
shAAV-206706
AAV-h-DDIT3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DDIT3 (DNA damage inducible transcript 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CEBPZ; CHOP; CHOP-10; CHOP10; GADD153
Description (Vector)
DDIT3 encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.
Gene ID
1649
Gene Name (Vector)
DNA damage inducible transcript 3
Gene Symbol
DDIT3
HGNC ID
HGNC:2726
ORF Size (aa)
510
ORF Size (bp)
510 bp
RefSeq ID
NM_004083
RefSeq Synonyms
NM_004083, NM_001195057, NM_001195056, NM_001195055, NM_001195054, NM_001195053, BC003637,
Species
human
UniGene ID
Hs.690217
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.