human DDC shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DDC.
shAAV-206697
AAV-h-DDC-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DDC (dopa decarboxylase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AADC
Description (Vector)
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Gene ID
1644
Gene Name (Vector)
dopa decarboxylase
Gene Symbol
DDC
HGNC ID
HGNC:2719
ORF Size (aa)
1443
ORF Size (bp)
1443 bp
RefSeq ID
NM_000790
RefSeq Synonyms
NM_001242890, NM_001242889, NM_001242888, NM_001242887, NM_001242886, NM_001082971, NM_000790, BC008366, BC000485,
Species
human
UniGene ID
Hs.359698
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.