human DCLK2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DCLK2.
shAAV-206656
AAV-h-DCLK2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DCLK2 (doublecortin like kinase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CL2; CLICK-II; CLICK2; CLIK2; DCAMKL2; DCDC3; DCDC3B; DCK2
Description (Vector)
DCLK2 encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified.
Gene ID
166614
Gene Name (Vector)
doublecortin like kinase 2
Gene Symbol
DCLK2
HGNC ID
HGNC:19002
ORF Size (aa)
2301
ORF Size (bp)
2301 bp
RefSeq ID
NM_001040260
RefSeq Synonyms
NM_001040261, NM_001040260, BC172430,
Species
human
UniGene ID
Hs.591683
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.