human DBI shRNA silencing AAV

Name
AAV-h-DBI-shRNA

Cat No
shAAV-206621

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human DBI.

shAAV-206621

AAV-h-DBI-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DBI (diazepam binding inhibitor, acyl-CoA binding protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ACBD1; ACBP; CCK-RP; EP

Description (Vector)

DBI encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene.

Gene ID

1622

Gene Name (Vector)

diazepam binding inhibitor, acyl-CoA binding protein

Gene Symbol

DBI

HGNC ID

HGNC:2690

ORF Size (aa)

315

RefSeq ID

NM_020548

RefSeq Synonyms

NM_020548, NM_001282636, NM_001282635, NM_001282634, NM_001282633, NM_001178043, NM_001178042, NM_001178041, NM_001178017, NM_001079863, NM_001079862, BC062996,

Species

human

UniGene ID

Hs.78888

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.