human DAO shRNA silencing AAV

Name
AAV-h-DAO-shRNA

Cat No
shAAV-206585

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human DAO.

shAAV-206585

AAV-h-DAO-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DAO (D-amino acid oxidase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DAAO; DAMOX; OXDA

Description (Vector)

DAO encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. DAO may play a role in the pathophysiology of schizophrenia.

Gene ID

1610

Gene Name (Vector)

D-amino acid oxidase

Gene Symbol

DAO

HGNC ID

HGNC:2671

ORF Size (aa)

1044

ORF Size (bp)

1044 bp

RefSeq ID

NM_001917

RefSeq Synonyms

NM_001917, BC074770, BC029057,

Species

human

UniGene ID

Hs.113227

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.