human CYP2D6 shRNA silencing AAV

Name
AAV-h-CYP2D6-shRNA

Cat No
shAAV-206492

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CYP2D6.

shAAV-206492

AAV-h-CYP2D6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CYP2D6 (cytochrome P450 family 2 subfamily D member 6). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1

Description (Vector)

CYP2D6 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

1565

Gene Name (Vector)

cytochrome P450 family 2 subfamily D member 6

Gene Symbol

CYP2D6

HGNC ID

HGNC:2625

ORF Size (aa)

1341

ORF Size (bp)

1341 bp

RefSeq ID

NM_000106

RefSeq Synonyms

NM_001025161, NM_000106, BC126858, BC106758, BC106757, BC075024, BC075023, BC067432,

Species

human

UniGene ID

Hs.648256

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.