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human IPO11 Adenovirus

Name 
Ad-h-IPO11
Cat No 
ADV-212343
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human IPO11.

ADV-212343
Ad-h-IPO11

Ready-to-use Adenovirus expressing Human IPO11 (importin 11). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
imp11; importin-11; Ran binding protein 11; ran-binding protein 11; RanBP11
Description (eCommerce)
Importin 11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates, and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Importin 11/IPO11 mediates the nuclear import of UBE2E3, and of RPL12 (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UI26].
Description (Vector)
Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 (PubMed 11032817)).(supplied by OMIM, Sep 2008)
Gene ID
51194
Gene Name (eCommerce)
importin 11
Gene Name (Vector)
importin 11
Gene Symbol
IPO11
HGNC ID
HGNC:20628
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2928
ORF Size (bp)
2928 bp
Protein Name (eCommerce)
Importin-11
RefSeq ID
NM_016338
RefSeq Synonyms
NM_016338, NM_001134779, BC033776,
Research Areas
Cell Biology,Translational Control,Transport
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
Importin 11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates, and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Importin 11/IPO11 mediates the nuclear import of UBE2E3, and of RPL12 (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UI26].
UniGene ID
Hs.482269
UniProt ID (eCommerce)
Q9UI26

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.