human CYP26A1 shRNA silencing AAV

Name
AAV-h-CYP26A1-shRNA

Cat No
shAAV-206465

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human CYP26A1.

shAAV-206465

AAV-h-CYP26A1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CYP26A1 (cytochrome P450 family 26 subfamily A member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CP26; CYP26; P450RAI; P450RAI1

Description (Vector)

CYP26A1 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported.

Gene ID

1592

Gene Name (Vector)

cytochrome P450 family 26 subfamily A member 1

Gene Symbol

CYP26A1

HGNC ID

HGNC:2603

ORF Size (aa)

1494

ORF Size (bp)

1494 bp

RefSeq ID

NM_000783

RefSeq Synonyms

NM_057157, NM_000783, BC157063, BC156283,

Species

human

UniGene ID

Hs.150595

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.