human CYP17A1 shRNA silencing AAV

Name
AAV-h-CYP17A1-shRNA

Cat No
shAAV-206446

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CYP17A1.

shAAV-206446

AAV-h-CYP17A1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CYP17A1 (cytochrome P450 family 17 subfamily A member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CPT7; CYP17; P450C17; S17AH

Description (Vector)

CYP17A1 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.

Gene ID

1586

Gene Name (Vector)

cytochrome P450 family 17 subfamily A member 1

Gene Symbol

CYP17A1

HGNC ID

HGNC:2593

ORF Size (aa)

1527

ORF Size (bp)

1527 bp

RefSeq ID

NM_000102

RefSeq Synonyms

NM_000102, BC063388, BC062997,

Species

human

UniGene ID

Hs.438016

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.