human CTSB shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CTSB.
shAAV-206264
AAV-h-CTSB-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CTSB (cathepsin B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
APPS; CPSB
Description (Vector)
CTSB is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene.
Gene ID
1508
Gene Name (Vector)
cathepsin B
Gene Symbol
CTSB
HGNC ID
HGNC:2527
ORF Size (aa)
1020
ORF Size (bp)
1020 bp
RefSeq ID
NM_001908
RefSeq Synonyms
NM_147783, NM_147782, NM_147781, NM_147780, NM_001908, NM_001317237, BC095408, BC010240,
Species
human
UniGene ID
Hs.520898
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.