human CTH shRNA silencing AAV

Name
AAV-h-CTH-shRNA

Cat No
shAAV-206233

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human CTH.

shAAV-206233

AAV-h-CTH-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CTH (cystathionine gamma-lyase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

CTH encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms.

Gene ID

1491

Gene Name (Vector)

cystathionine gamma-lyase

Gene Symbol

CTH

HGNC ID

HGNC:2501

ORF Size (aa)

1218

ORF Size (bp)

1218 bp

RefSeq ID

NM_001902

RefSeq Synonyms

NM_153742, NM_001902, NM_001190463, BC015807,

Species

human

UniGene ID

Hs.19904

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.