human CROT shRNA silencing AAV

Name
AAV-h-CROT-shRNA

Cat No
shAAV-206033

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human CROT.

shAAV-206033

AAV-h-CROT-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CROT (carnitine O-octanoyltransferase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

COT

Description (Vector)

CROT encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.

Gene ID

54677

Gene Name (Vector)

carnitine O-octanoyltransferase

Gene Symbol

CROT

HGNC ID

HGNC:2366

ORF Size (aa)

1839

ORF Size (bp)

1839 bp

RefSeq ID

NM_021151

RefSeq Synonyms

NM_021151, NM_001243745, NM_001143935, BC051874, BC039004,

Species

human

UniGene ID

Hs.125039

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.