human CPT1A shRNA silencing AAV

Name
AAV-h-CPT1A-shRNA

Cat No
shAAV-205937

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human CPT1A.

shAAV-205937

AAV-h-CPT1A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CPT1A (carnitine palmitoyltransferase 1A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CPT1; CPT1-L; L-CPT1

Description (Vector)

The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

1374

Gene Name (Vector)

carnitine palmitoyltransferase 1A

Gene Symbol

CPT1A

HGNC ID

HGNC:2328

ORF Size (aa)

2271

ORF Size (bp)

2271 bp

RefSeq ID

NM_001876

RefSeq Synonyms

NM_001876, NM_001031847, BC000185,

Species

human

UniGene ID

Hs.503043

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.