human COPS2 shRNA silencing AAV

Name 
AAV-h-COPS2-shRNA
Cat No 
shAAV-205765
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human COPS2.

shAAV-205765
AAV-h-COPS2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human COPS2 (COP9 signalosome subunit 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ALIEN; alien homolog; COP9 constitutive photomorphogenic homolog subunit 2; COP9 signalosome complex subunit 2; CSN2; JAB1-containing signalosome subunit 2; SGN2; signalosome subunit 2; thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP15; TRIP-15
Description (eCommerce)
CSN2 is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals a function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases. CSN2 has also been demonstrated to interact with the sin3A corepressor complex as well as the thyroid hormone and vitamin D3 receptor to mediate gene repression.
Gene ID
9318
Gene Name (eCommerce)
COP9 signalosome subunit 2
Gene Name (Vector)
COP9 signalosome subunit 2
Gene Symbol
COPS2
HGNC ID
HGNC:30747
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1332
ORF Size (bp)
1332 bp
Protein Name (eCommerce)
COP9 signalosome complex subunit 2
RefSeq ID
NM_004236
RefSeq Synonyms
NM_004236, NM_001143887, BC012629,
Research Areas
Neurobiology,Neurodevelopment,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,developmental_biology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
CSN2 is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals a function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases. CSN2 has also been demonstrated to interact with the sin3A corepressor complex as well as the thyroid hormone and vitamin D3 receptor to mediate gene repression.
UniGene ID
Hs.369614
UniProt ID (eCommerce)
P61201

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.