human CNTF shRNA silencing AAV

Name
AAV-h-CNTF-shRNA

Cat No
shAAV-205635

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CNTF.

shAAV-205635

AAV-h-CNTF-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CNTF (ciliary neurotrophic factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HCNTF

Description (Vector)

CNTF is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.

Gene ID

1270

Gene Name (Vector)

ciliary neurotrophic factor

Gene Symbol

CNTF

HGNC ID

HGNC:2169

ORF Size (aa)

603

ORF Size (bp)

603 bp

RefSeq ID

NM_000614

RefSeq Synonyms

NM_000614, BC074964, BC074963, BC069167, BC068030,

Species

human

UniGene ID

Hs.715806

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.