human CNOT10 shRNA silencing AAV

Name
AAV-h-CNOT10-shRNA

Cat No
shAAV-205604

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human CNOT10.

shAAV-205604

AAV-h-CNOT10-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CNOT10 (CCR4-NOT transcription complex subunit 10). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

80

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CCR4-NOT transcription complex subunit 10

Description (eCommerce)

CCR4-NOT transcription complex subunit 10 (CNOT10) is a component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H9A5].

Gene ID

25904

Gene Name (eCommerce)

CCR4-NOT transcription complex subunit 10

Gene Name (Vector)

CCR4-NOT transcription complex subunit 10

Gene Symbol

CNOT10

HGNC ID

HGNC:23817

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2154

ORF Size (bp)

2154 bp

Protein Name (eCommerce)

CCR4-NOT transcription complex subunit 10

RefSeq ID

NM_015442

RefSeq Synonyms

NM_015442, NM_001256742, NM_001256741, BC002931, BC002928,

Research Areas

Gene Expression,RNA Processing,Transcription Factor/Regulator,Translational Control

Research Areas (Faceted)

cell_biology,genetics,transcription_translation

Species

human

Target Sentence

CCR4-NOT transcription complex subunit 10 (CNOT10) is a component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H9A5].

UniGene ID

Hs.444851

UniProt ID (eCommerce)

Q9H9A5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.