human CMA1 shRNA silencing AAV

Cat. No: shAAV-205538

Availability: 6-8 weeks

Name: AAV-h-CMA1-shRNA

This is an AAV expressing shRNA for silencing of Human CMA1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CMA1
Gene Name: chymase 1
Gene ID: 1215
Gene Synonyms: chymase; CYH; MCT1
ORF Size: 411 bp
RefSeq#: NM_001836
Gene Description: CMA1 product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. CMA1 maps to 14q11.2 in a cluster of genes encoding other proteases.
UniGene ID: Hs.135626
HGNC ID: HGNC:2097