human CLNK shRNA silencing AAV

Name
AAV-h-CLNK-shRNA

Cat No
shAAV-205489

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CLNK.

shAAV-205489

AAV-h-CLNK-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CLNK (cytokine dependent hematopoietic cell linker). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MIST

Description (Vector)

MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 (PubMed 10562326); Goitsuka et al., 2000, 2001 (PubMed 10744659) (PubMed 11463797)).(supplied by OMIM, Mar 2008)

Gene ID

116449

Gene Name (Vector)

cytokine dependent hematopoietic cell linker

Gene Symbol

CLNK

HGNC ID

HGNC:17438

ORF Size (aa)

1287

ORF Size (bp)

1287 bp

RefSeq ID

NM_052964

RefSeq Synonyms

NM_052964, BC137556, BC137553,

Species

human

UniGene ID

Hs.678910

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.