human CLN6 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CLN6.
shAAV-205485
AAV-h-CLN6-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CLN6 (ceroid-lipofuscinosis, neuronal 6, late infantile, variant). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CLN4A; HsT18960; nclf
Description (Vector)
CLN6 is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function.
Gene ID
54982
Gene Name (Vector)
ceroid-lipofuscinosis, neuronal 6, late infantile, variant
Gene Symbol
CLN6
HGNC ID
HGNC:2077
ORF Size (aa)
936
ORF Size (bp)
936 bp
RefSeq ID
NM_017882
RefSeq Synonyms
NM_017882, BC013130, BC010849,
Species
human
UniGene ID
Hs.584921
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.