human CLDN6 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CLDN6.
shAAV-205386
AAV-h-CLDN6-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CLDN6 (claudin 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.
Gene ID
9074
Gene Name (Vector)
claudin 6
Gene Symbol
CLDN6
HGNC ID
HGNC:2048
ORF Size (aa)
663
RefSeq ID
NM_021195
RefSeq Synonyms
NM_021195, BC008934,
Species
human
UniGene ID
Hs.533779
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.