human CLDN19 shRNA silencing AAV

Name
AAV-h-CLDN19-shRNA

Cat No
shAAV-205376

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CLDN19.

shAAV-205376

AAV-h-CLDN19-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CLDN19 (claudin 19). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HOMG5

Description (Vector)

The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Gene ID

149461

Gene Name (Vector)

claudin 19

Gene Symbol

CLDN19

HGNC ID

HGNC:2040

ORF Size (aa)

636

RefSeq ID

NM_148960

RefSeq Synonyms

NM_148960, NM_001185117, NM_001123395, BC030524,

Species

human

UniGene ID

Hs.496270

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.