human CLCA2 shRNA silencing AAV

Name
AAV-h-CLCA2-shRNA

Cat No
shAAV-205339

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CLCA2.

shAAV-205339

AAV-h-CLCA2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CLCA2 (chloride channel accessory 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CACC; CaCC-3; CACC3; CLCRG2

Description (Vector)

CLCA2 belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer.

Gene ID

9635

Gene Name (Vector)

chloride channel accessory 2

Gene Symbol

CLCA2

HGNC ID

HGNC:2016

ORF Size (aa)

2832

ORF Size (bp)

2832 bp

RefSeq ID

NM_006536

RefSeq Synonyms

NM_006536, BC041096,

Species

human

UniGene ID

Hs.241551

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.