human CHRNA3 shRNA silencing AAV

Name
AAV-h-CHRNA3-shRNA

Cat No
shAAV-205209

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CHRNA3.

shAAV-205209

AAV-h-CHRNA3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

LNCR2; NACHRA3; PAOD2

Description (Vector)

This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.

Gene ID

1136

Gene Name (Vector)

cholinergic receptor nicotinic alpha 3 subunit

Gene Symbol

CHRNA3

HGNC ID

HGNC:1957

ORF Size (aa)

1515

ORF Size (bp)

1515 bp

RefSeq ID

NM_000743

RefSeq Synonyms

NM_001166694, NM_000743, BC098443, BC006114, BC002996, BC001642, BC000513,

Species

human

UniGene ID

Hs.89605

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.