human CHMP4C shRNA silencing AAV

Name 
AAV-h-CHMP4C-shRNA
Cat No 
shAAV-205167
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CHMP4C.

shAAV-205167
AAV-h-CHMP4C-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CHMP4C (charged multivesicular body protein 4C). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Shax3; SNF7-3; VPS32C
Description (Vector)
CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 (PubMed 16730941)).(supplied by OMIM, Mar 2008)
Gene ID
92421
Gene Name (Vector)
charged multivesicular body protein 4C
Gene Symbol
CHMP4C
HGNC ID
HGNC:30599
ORF Size (aa)
702
ORF Size (bp)
702 bp
RefSeq ID
NM_152284
RefSeq Synonyms
NM_152284, BC014321,
Species
human
UniGene ID
Hs.183861

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.