human CHM shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CHM.
shAAV-205156
AAV-h-CHM-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CHM (CHM, Rab escort protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DXS540; GGTA; HSD-32; REP-1; TCD
Description (Vector)
CHM encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene ID
1121
Gene Name (Vector)
CHM, Rab escort protein 1
Gene Symbol
CHM
HGNC ID
HGNC:1940
ORF Size (aa)
1962
ORF Size (bp)
1962 bp
RefSeq ID
NM_000390
RefSeq Synonyms
NM_001320959, NM_001145414, NM_000390, BC172532, BC156457,
Species
human
UniGene ID
Hs.496449
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.