human CENPA shRNA silencing AAV

Name
AAV-h-CENPA-shRNA

Cat No
shAAV-204950

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human CENPA.

shAAV-204950

AAV-h-CENPA-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CENPA (centromere protein A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CenH3; CENP-A

Description (Vector)

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene ID

1058

Gene Name (Vector)

centromere protein A

Gene Symbol

CENPA

HGNC ID

HGNC:1851

ORF Size (aa)

423

ORF Size (bp)

423 bp

RefSeq ID

NM_001809

RefSeq Synonyms

NM_001809, NM_001042426, BC002703, BC000881,

Species

human

UniGene ID

Hs.1594

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.