human CDH4 shRNA silencing AAV

Name
AAV-h-CDH4-shRNA

Cat No
shAAV-204825

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CDH4.

shAAV-204825

AAV-h-CDH4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CDH4 (cadherin 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CAD4; R-CAD; RCAD

Description (Vector)

CDH4 is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene.

Gene ID

1002

Gene Name (Vector)

cadherin 4

Gene Symbol

CDH4

HGNC ID

HGNC:1763

ORF Size (aa)

2751

ORF Size (bp)

2751 bp

RefSeq ID

NM_001794

RefSeq Synonyms

NM_001794, NM_001252339, NM_001252338, BC112150, BC101651,

Species

human

UniGene ID

Hs.598638

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.