human CDC42EP1 shRNA silencing AAV

Name
AAV-h-CDC42EP1-shRNA

Cat No
shAAV-204764

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CDC42EP1.

shAAV-204764

AAV-h-CDC42EP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CDC42EP1 (CDC42 effector protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

55 kDa bone marrow stromal/endothelial cell protein; binder of Rho GTPases 5; BORG5; CDC42 effector protein (Rho GTPase binding) 1; cdc42 effector protein 1; CEP1; MSE55; serum constituent protein; serum protein MSE55

Description (eCommerce)

BORG5 (binder of Rho GTPases 5) is part of a family of proteins that function as negative regulators of CDC42 Rho GTPase signaling. The Borg family of proteins are also known as CEPs (Cdc effector proteins) and have been shown to act downstream of Cdc42 to influence the assembly of actin filaments and changes in cell shape. BORG5 plays a role in mannose receptor-mediated phagocytosis of unopsonized Pneumocystis organisms by alveolar macrophages.

Description (Vector)

CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. This protein is secreted and is primarily found in bone marrow.

Gene ID

11135

Gene Name (eCommerce)

CDC42 effector protein 1

Gene Name (Vector)

CDC42 effector protein 1

Gene Symbol

CDC42EP1

HGNC ID

HGNC:17014

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1155

ORF Size (bp)

1155 bp

Protein Name (eCommerce)

Cdc42 effector protein 1

RefSeq ID

NM_152243

RefSeq Synonyms

NM_152243, BC009356,

Research Areas

Cytoskeleton,Golgi Apparatus,Metabolism/Metabolic Process,Rho Signaling,Signal Transduction

Research Areas (Faceted)

signal_transduction,cell_biology,metabolism,signal_transduction

Species

human

Target Sentence

BORG5 (binder of Rho GTPases 5) is part of a family of proteins that function as negative regulators of CDC42 Rho GTPase signaling. The Borg family of proteins are also known as CEPs (Cdc effector proteins) and have been shown to act downstream of Cdc42 to influence the assembly of actin filaments and changes in cell shape. BORG5 plays a role in mannose receptor-mediated phagocytosis of unopsonized Pneumocystis organisms by alveolar macrophages.

UniGene ID

Hs.225356

UniProt ID (eCommerce)

Q00587

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.