human CDC42BPB shRNA silencing AAV

Name 
AAV-h-CDC42BPB-shRNA
Cat No 
shAAV-204762
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CDC42BPB.

shAAV-204762
AAV-h-CDC42BPB-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CDC42BPB (CDC42 binding protein kinase beta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CDC42 binding protein kinase beta (DMPK-like); CDC42-binding protein kinase beta; CDC42BP-beta; DMPK-like beta; MRCK beta; MRCKB; myotonic dystrophy kinase-related CDC42-binding kinase beta; myotonic dystrophy protein kinase-like beta; serine/threonine-protein kinase MRCK beta
Description (eCommerce)
CDC42-binding protein kinase beta (CDC42BPB) contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK [taken from NCBI Entrez Gene (Gene ID: 9578)].
Description (Vector)
CDC42BPB encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization.
Gene ID
9578
Gene Name (eCommerce)
CDC42 binding protein kinase beta
Gene Name (Vector)
CDC42 binding protein kinase beta
Gene Symbol
CDC42BPB
HGNC ID
HGNC:1738
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5136
ORF Size (bp)
5136 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase MRCK beta
RefSeq ID
NM_006035
RefSeq Synonyms
NM_006035, BC156936, BC155541,
Research Areas
Cytoskeleton,Kinase/Phosphatase,Signal Transduction,Zinc-finger
Research Areas (Faceted)
signal_transduction,cell_biology
Species
human
Target Sentence
CDC42-binding protein kinase beta (CDC42BPB) contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK [taken from NCBI Entrez Gene (Gene ID: 9578)].
UniGene ID
Hs.654634
UniProt ID (eCommerce)
Q9Y5S2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.