human CD2BP2 shRNA silencing AAV

Name
AAV-h-CD2BP2-shRNA

Cat No
shAAV-204626

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human CD2BP2.

shAAV-204626

AAV-h-CD2BP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CD2BP2 (CD2 cytoplasmic tail binding protein 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CD2 antigen cytoplasmic tail-binding protein 2; CD2 cytoplasmic domain-binding protein 2; CD2 tail-binding protein 2; FWP010; LIN1; PPP1R59; protein phosphatase 1, regulatory subunit 59; Snu40; U5 snRNP 52K protein; U5-52K

Description (eCommerce)

CD2BP2 is involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assemblyÂ [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O95400].

Description (Vector)

CD2BP2 encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined.

Gene ID

10421

Gene Name (eCommerce)

CD2 cytoplasmic tail binding protein 2

Gene Name (Vector)

CD2 cytoplasmic tail binding protein 2

Gene Symbol

CD2BP2

HGNC ID

HGNC:1656

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1026

ORF Size (bp)

1026 bp

Protein Name (eCommerce)

CD2 antigen cytoplasmic tail-binding protein 2

RefSeq ID

NM_006110

RefSeq Synonyms

NM_006110, NM_001243646, BC001947, BC000495,

Research Areas

Gene Expression,Kinase/Phosphatase,mRNA Processing,mRNA Splicing,RNA Processing,Spliceosome

Research Areas (Faceted)

cell_biology,genetics,signal_transduction,transcription_translation

Species

human

Target Sentence

UniGene ID

Hs.202677

UniProt ID (eCommerce)

O95400

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.