human CCNB2 shRNA silencing AAV

Name 
AAV-h-CCNB2-shRNA
Cat No 
shAAV-204479
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CCNB2.

shAAV-204479
AAV-h-CCNB2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CCNB2 (cyclin B2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
G2/mitotic-specific cyclin-B2; HsT17299
Description (eCommerce)
Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control [taken from NCBI Entrez Gene (Gene ID: 9133)].
Description (Vector)
Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.
Gene ID
9133
Gene Name (eCommerce)
cyclin B2
Gene Name (Vector)
cyclin B2
Gene Symbol
CCNB2
HGNC ID
HGNC:1580
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1197
ORF Size (bp)
1197 bp
Protein Name (eCommerce)
G2/mitotic-specific cyclin-B2
RefSeq ID
NM_004701
RefSeq Synonyms
NM_004701, BC105112, BC105086,
Research Areas
Breast Cancer,Cancer,Cell Cycle,Cell Division,Cytoskeleton,DNA Damage/Repair,DNA Replication,Golgi Apparatus,Host-Virus Interactions,Immunology,Meiosis,p53 Signaling,Signal Transduction,TGF-beta Signaling
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,signal_transduction,transcription_translation
Species
human
Target Sentence
Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control [taken from NCBI Entrez Gene (Gene ID: 9133)].
UniGene ID
Hs.194698
UniProt ID (eCommerce)
O95067

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.