human CCNA2 shRNA silencing AAV

Name 
AAV-h-CCNA2-shRNA
Cat No 
shAAV-204473
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CCNA2.

shAAV-204473
AAV-h-CCNA2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CCNA2 (cyclin A2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CCN1; CCNA; Cyclin A; cyclin-A; cyclin-A2
Description (eCommerce)
The protein encoded by the gene CCNA2, Cyclin A2, belongs to the highly conserved cyclin family. Members of the cyclin family are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, Cyclin A2 is expressed in all tissues tested. Cyclin A2 binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions [taken from NCBI Entrez Gene ID: 890].
Description (Vector)
CCNA2 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.
Gene ID
890
Gene Name (eCommerce)
cyclin A2
Gene Name (Vector)
cyclin A2
Gene Symbol
CCNA2
HGNC ID
HGNC:1578
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1299
ORF Size (bp)
1299 bp
Protein Name (eCommerce)
Cyclin-A2
RefSeq ID
NM_001237
RefSeq Synonyms
NM_001237, BC104787, BC104783,
Research Areas
Cancer,Cell Cycle,Cell Division,DNA Damage/Repair,Host-Virus Interactions,Interleukin Signaling,p53 Signaling,Signal Transduction,Viral Carcinogenesis
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation,infectious_disease,signal_transduction,immunology,cancer,infectious_disease
Species
human
Target Sentence
The protein encoded by the gene CCNA2, Cyclin A2, belongs to the highly conserved cyclin family. Members of the cyclin family are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, Cyclin A2 is expressed in all tissues tested. Cyclin A2 binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions [taken from NCBI Entrez Gene ID: 890].
UniGene ID
Hs.58974
UniProt ID (eCommerce)
P20248

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.