human CCM2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CCM2.
shAAV-204469
AAV-h-CCM2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CCM2 (CCM2 scaffolding protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C7orf22; OSM; PP10187
Description (Vector)
CCM2 encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
83605
Gene Name (Vector)
CCM2 scaffolding protein
Gene Symbol
CCM2
HGNC ID
HGNC:21708
ORF Size (aa)
1335
ORF Size (bp)
1335 bp
RefSeq ID
NM_031443
RefSeq Synonyms
NM_031443, NM_001167935, NM_001167934, NM_001029835, BC063663, BC016832, BC008859, BC004903,
Species
human
UniGene ID
Hs.148272
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.