human CCL23 shRNA silencing AAV

Name
AAV-h-CCL23-shRNA

Cat No
shAAV-204435

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CCL23.

shAAV-204435

AAV-h-CCL23-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CCL23 (C-C motif chemokine ligand 23). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CK-BETA-8; Ckb-8; Ckb-8-1; CKb8; hmrp-2a; MIP-3; MIP3; MPIF-1; SCYA23

Description (Vector)

CCL23 is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist at CC chemokine receptor 1. Two alternatively spliced variants encoding different active isoforms have been identified.

Gene ID

6368

Gene Name (Vector)

C-C motif chemokine ligand 23

Gene Symbol

CCL23

HGNC ID

HGNC:10622

ORF Size (aa)

414

ORF Size (bp)

414 bp

RefSeq ID

NM_005064

RefSeq Synonyms

NM_145898, NM_005064, BC143310, BC093970,

Species

human

UniGene ID

Hs.169191

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.