human CBLC shRNA silencing AAV

Name
AAV-h-CBLC-shRNA

Cat No
shAAV-204164

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CBLC.

shAAV-204164

AAV-h-CBLC-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CBLC (Cbl proto-oncogene C). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Cas-Br-M (murine) ecotropic retroviral transforming sequence c; Cas-Br-M (murine) ectropic retroviral transforming sequence c; Cbl proto-oncogene C, E3 ubiquitin protein ligase; Cbl proto-oncogene, E3 ubiquitin protein ligase C; CBL-3; CBL-SL; E3 ubiquitin-protein ligase CBL-C; RING finger protein 57; RING-type E3 ubiquitin transferase CBL-C; RNF57; SH3-binding protein CBL-3; SH3-binding protein CBL-C; signal transduction protein CBL-C

Description (eCommerce)

CBLC is a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases [taken from NCBI Entrez Gene (Gene ID: 23624)].

Description (Vector)

CBLC encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene ID

23624

Gene Name (eCommerce)

Cbl proto-oncogene C

Gene Name (Vector)

Cbl proto-oncogene C

Gene Symbol

CBLC

HGNC ID

HGNC:15961

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1425

ORF Size (bp)

1425 bp

Protein Name (eCommerce)

E3 ubiquitin-protein ligase CBL-C

RefSeq ID

NM_012116

RefSeq Synonyms

NM_012116, NM_001130852, BC028915,

Research Areas

Cancer,EGFR Signaling,GPCR Signaling,Immunology,Insulin Signaling,JAK-STAT Signaling,Leukemia,Signal Transduction,T-cell Receptor Signaling,Zinc-finger

Research Areas (Faceted)

cancer,cell_biology,immunology,signal_transduction

Species

human

Target Sentence

UniGene ID

Hs.466907

UniProt ID (eCommerce)

Q9ULV8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.