human CAV3 shRNA silencing AAV

Name
AAV-h-CAV3-shRNA

Cat No
shAAV-204150

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human CAV3.

shAAV-204150

AAV-h-CAV3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CAV3 (caveolin 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

LGMD1C; LQT9; VIP-21; VIP21

Description (Vector)

CAV3 encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites.

Gene ID

859

Gene Name (Vector)

caveolin 3

Gene Symbol

CAV3

HGNC ID

HGNC:1529

ORF Size (aa)

456

ORF Size (bp)

456 bp

RefSeq ID

NM_001234

RefSeq Synonyms

NM_033337, NM_001234, BC102037, BC102036, BC102033, BC069368,

Species

human

UniGene ID

Hs.98303

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.