human CAMKK1 shRNA silencing AAV

Name 
AAV-h-CAMKK1-shRNA
Cat No 
shAAV-204004
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CAMKK1.

shAAV-204004
AAV-h-CAMKK1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
calcium/calmodulin-dependent protein kinase kinase 1; calcium/calmodulin-dependent protein kinase kinase 1, alpha; calcium/calmodulin-dependent protein kinase kinase alpha; caM-kinase IV kinase; caM-kinase kinase 1; caM-kinase kinase alpha; caMKK 1; caM-KK 1; CaMKK alpha; caM-KK alpha; CAMKK alpha protein; CAMKKA
Description (eCommerce)
CaMKK alpha is a calcium/calmodulin-dependent protein kinase that phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. CaMKK alpha is involved in regulating cell apoptosis. It promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8N5S9].
Description (Vector)
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene.
Gene ID
84254
Gene Name (eCommerce)
calcium/calmodulin dependent protein kinase kinase 1
Gene Name (Vector)
calcium/calmodulin dependent protein kinase kinase 1
Gene Symbol
CAMKK1
HGNC ID
HGNC:1469
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1563
ORF Size (bp)
1563 bp
Protein Name (eCommerce)
Calcium/calmodulin-dependent protein kinase kinase 1
RefSeq ID
NM_172207
RefSeq Synonyms
NM_172207, NM_172206, NM_032294, BC043487, BC031647,
Research Areas
Cardiac Hypertrophy,Cardiology,Cardiovascular,Gene Expression,Kinase/Phosphatase,Neurobiology,Signal Transduction
Research Areas (Faceted)
cardiovascular,cell_biology,neurobiology,signal_transduction
Species
human
Target Sentence
CaMKK alpha is a calcium/calmodulin-dependent protein kinase that phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. CaMKK alpha is involved in regulating cell apoptosis. It promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8N5S9].
UniGene ID
Hs.8417
UniProt ID (eCommerce)
Q8N5S9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.